Lipid Metabolism — Medical Biochemistry

Biochemistry · Basic Sciences

How it begins

Análisis exhaustivo de la digestión, transporte, oxidación, síntesis y regulación de los lípidos, con énfasis en la fisiopatología y las correlaciones clínicas de relevancia médica.

What it covers

1. Lipid Metabolism
2. Generalities and Classification of Lipids
3. · Biochemical Classification
4. · Fatty Acids: Nomenclature and Properties
5. Digestion and Intestinal Absorption of Lipids
6. · Emulsification and Action of Bile Salts
7. · Digestive Enzymes: Mechanism and Kinetics
8. · Mixed Micelle Formation and Enterocyte Absorption
9. · Re-synthesis of Triglycerides and Formation of Chylomicrons
10. · Lymphatic Transport of Chylomicrons
11. Plasma Lipoproteins: Structure, Metabolism and Receptors
12. · Classification and Physicochemical Properties
13. · Exogenous Route: Chylomicron Metabolism
14. · Endogenous Pathway: VLDL → IDL → LDL metabolism
15. · The LDL Receptor (LDLr) — Brown and Goldstein Cycle
16. · Reverse Cholesterol Transport (CRT) — Via HDL
17. β-Mitochondrial Oxidation of Fatty Acids
18. · Activation of Fatty Acids: Acyl-CoA Synthetase
19. · Carnitine-Acylcarnitine System: The Mitochondrial Portal
20. · The Four Reactions of the β-Oxidation Cycle
21. · Energy Performance of β-Oxidation
22. · β-Oxidation of Unsaturated Fatty Acids
23. · β-Peroxisomal Oxidation
24. Ketogenesis and Ketolysis
25. · Conditions that Favor Ketogenesis
26. · Ketone Body Biosynthetic Pathway
27. · Ketolysis in Extrahepatic Tissues
28. De Novo Lipogenesis: Fatty Acid Synthesis
29. · Export of Mitochondrial Acetyl-CoA: The Citrate Shuttle
30. · Acetyl-CoA Carboxylase (ACC): The Central Regulatory Enzyme
31. · Fatty Acid Synthase (FAS / FASN): Multifunctional Complex
32. · Elongation and Desaturation of Fatty Acids
33. Cholesterol Metabolism
34. · The Mevalonate Pathway: Endogenous Cholesterol Synthesis
35. · Regulation of Cholesterol Synthesis — SREBP System
36. · Synthesis of Bile Acids
37. · Steroid Hormone Synthesis
38. Phospholipid and Sphingolipid Metabolism
39. · Synthesis of Glycerophospholipids
40. · Sphingolipid Metabolism
41. Eicosanoids: Prostaglandins, Thromboxanes and Leukotrienes
42. · Release of Arachidonic Acid
43. · Cyclooxygenase (COX) Pathway — Prostaglandins and Thromboxanes
44. · Lipooxygenase (LOX) Pathway — Leukotrienes and Lipoxins
45. Hormonal Regulation of Lipid Metabolism
46. · Insulin — The Anabolic Switch
47. · Glucagon and Catecholamines — The Catabolic Switch
48. · AMPK — The Cellular Energy Sensor
49. · PPARs — Nuclear Lipid Receptors
50. Clinical Correlations: Dyslipidemias and Lipid Metabolism Errors
51. · Fredrickson-WHO Classification of Hyperlipoproteinemias
52. · Metabolic Syndrome and Insulin Resistance
53. · Nonalcoholic Fatty Liver (NAFLD/MASLD)
54. · Hypotriglyceridemia and Severe Hypertriglyceridemia
55. · Gene Therapy in Lipid Metabolism