Emergencies: Septic Patient

Emergencies: Septic Patient — Expert Level Reference

How it begins

De la disfunción endotelial y microcirculatoria al soporte hemodinámico guiado por objetivos. Un análisis fisiopatológico y clínico exhaustivo sobre el cribado, resucitación con fluidos, farmacología vasoactiva y optimización antimicrobiana en el servicio de urgencias.

What it covers

1. Conceptual evolution: from SIRS to Sepsis-3
2. · The era of Sepsis-1 and Sepsis-2: the focus on inflammation (SIRS)
3. · The Sepsis Consensus-3 (2016): deregulated organ dysfunction
4. · Redefinition of Septic Shock in Sepsis-3
5. Epidemiology, risk factors and global burden
6. · Epidemiological burden: global estimates
7. · Risk factors and highly vulnerable populations
8. · Epidemiological distribution of the sources of origin
9. Advanced molecular and cellular pathophysiology
10. · Molecular recognition phase: PAMPs, DAMPs and Pattern Recognition Receptors (PRRs)
11. · Endothelial dysfunction and glycocalyx degradation
12. · Sepsis-induced coagulopathy (SIC) and Disseminated Intravascular Coagulation (DIC)
13. · Mitochondrial dysfunction and cellular bioenergetics: "cellular hibernation"
14. Multi-organ dysfunction (MODS): systems pathophysiology
15. · 1. Cardiovascular Dysfunction and Septic Cardiomyopathy
16. · 2. Respiratory Dysfunction and Acute Respiratory Distress Syndrome (ARDS)
17. · 3. Sepsis-Induced Acute Kidney Injury (S-AKI)
18. · 4. Neurological Dysfunction: Sepsis Associated Encephalopathy (SAE)
19. · 5. Liver and Gastrointestinal Dysfunction and Loss of the Mucous Barrier
20. Early identification in emergencies: screening tools
21. · Critical comparison of scales: SIRS, qSOFA, NEWS2 and SOFA
22. · The Golden Window of Opportunity: the 1-Hour Bundle
23. Semiology and clinical spectrum of septic shock
24. · Hemodynamic Phenotypes: Hyperdynamic Shock vs. Hypodynamic
25. · Evaluation of Peripheral Perfusion: semiological tools
26. Microbiological evaluation and biomarkers
27. · Blood cultures in emergencies: technique, volume and opportunity
28. · Rapid Molecular Identification Panels (FilmArray / Multiplex PCR)
29. · Biomarkers: Procalcitonin (PCT) versus C-Reactive Protein (CRP)
30. · The Kinetics of Serum Lactate as a Marker of Perfusion and Clearance
31. Physiology of fluid resuscitation
32. · The classic guideline of 30 mL/kg: advantages and limitations
33. · Choice of crystalloid: 0.9% Saline Solution versus Balanced Crystalloids
34. · Pathophysiology of volume overload and tissue damage
35. · Dynamic Evaluation of Volume Response (Fluid Responsiveness)
36. Vasopressor and inotrope therapy
37. · Norepinephrine: the vasopressor of absolute choice
38. · The safety of peripheral access for vasopressors
39. · Vasopressin as a second adjuvant agent
40. · Dobutamine in Septic Cardiomyopathy
41. Empirical antimicrobial therapy and PK/PD optimization
42. · Risk stratification for multidrug-resistant (MDR) microorganisms
43. · Effect of sepsis on pharmacokinetics (PK) and pharmacodynamics (PD)
44. · Extended and continuous infusion strategies of beta-lactams
45. Control of the focus of infection (Source Control)
46. · Ubi pus, ibi evacuate: the biomechanical principle of sepsis
47. Corticosteroids and adjuvant therapies in sepsis
48. · Corticotherapy in Refractory Septic Shock
49. · The fall of Marik's "Metabolic Combo"
50. · Extracorporeal Blood Purification Therapies
51. Advanced hemodynamic monitoring and clinical ultrasound (POCUS)
52. · The Blood Line: beyond the numerical value of Blood Pressure
53. · Directed Clinical Ultrasound (POCUS) in Distributive Shock
54. · Central Venous Oxygen Saturation (ScvO₂) and Metabolic Interactions
55. Sepsis in special populations
56. · 1. Sepsis in the Elderly and Frail Patient
57. · 2. Obstetric Sepsis: Physiological Adaptation of Pregnancy
58. · 3. Febrile Neutropenic Patient in the Emergency Room
59. Post-sepsis syndrome and integrated decision flow
60. · Post-Intensive Care and Post-Sepsis Syndrome (PICS)
61. · Integrated Decision Flow in Emergencies (Sepsis Code Checklist)